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Methodologist's Razor
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Surrogate Dispatches
Misunderstandings between empirical and theoretical scientists
The Poincaré-Lippman gap is an implicit problem in biomedical research when empirical scientists borrow mathematical tools.
Nov 13, 2025 • Manjari Narayan
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Biomarker Qualification
Aug 18, 2025 • Manjari Narayan
Sewall Wright and John Tukey on Path Analysis in 1952
Dec 2, 2024 • Manjari Narayan
Intercurrent Events
Jul 30, 2025 • Manjari Narayan
Neurostats Digest #3
Apr 30, 2025 • Manjari Narayan

Digests

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Neurostats Digest #6
Blood biomarkers, responders as a causal construct, low vs. high risk use-cases of biomarkers
Nov 21, 2025 • Manjari Narayan
Neurostats Digest #5
Notes round up on theoretical psychiatry, causal inference, and understanding papers
Oct 15, 2025 • Manjari Narayan
Neurostats Digest #4
Methodological reductions, primitive epistemic status of biomarkers
May 31, 2025 • Manjari Narayan
Neurostats Digest #3
Statistical transformations, virtual twins, progress in methodological discovery
Apr 30, 2025 • Manjari Narayan
Neurostats Digest #2
Select links and reading on regulatory science, free energy principle, vitamin-D interventions, preterm birth interventions
Jan 31, 2025 • Manjari Narayan

Surrogate Dispatches

Request for Information: Synthetic Datasets
Share how you validate synthetic data as a proxy for the real data
Nov 14, 2025 • Manjari Narayan
Biomarker Qualification
Qualification is to regulators what validation is to scientists
Aug 18, 2025 • Manjari Narayan
Predictive (in)validity
Translational probabilities of success and selection bias
May 12, 2025 • Manjari Narayan
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